Cryptocurrency Incentivized, Blockchain Recorded Peer Review (CIBR)

Introduction

Science has a reproducibility crisis. As a result there is an active debate in the scientific community on how to improve the Peer Review process. Retraction rates are also on the rise and there is ongoing discontent over publicly funded science being held behind paywalls.

We believe a large part of this market dysfunction is a result of the peer review process lacking a price signal. Ludwig von Mises wrote very elegantly about the Economic Calculation Problem in the socialist commonwealth. This work demonstrated the critical information pricing signals convey and the disastrous consequences that occur when prices are made illegal.

Most peer review is performed for free by 2-3 highly specialized and valuable individuals donating their time. Free work is always deprioritized over paid work. 42% of peer reviews are turned down due to the reviewers having other work competing for their time. Most reviewers are also anonymous. Some journals are thankfully experimenting with non-anonymous peer review but we believe it is equally important to experiment with bringing price signals into the peer review process.

Prices can capture time value and urgency. Prices can also reflect fairly straightforward in-silico verification of primary data or even sponsor complete wet lab reproduction of the work. It is important for Peer review to have pricing signals so this market speciation can occur. Gold, Silver and Bronze level reviews would help the reader to understand the magnitude of reproduction of the work.

Without this important communication of value, free peer review by 2-3 very busy and specialized individuals will never be thorough enough to fact check the complexity of a manuscript with over a dozen specialized authors.

Methods

We describe the use of cryptocurrencies to incentivize peer review. To address financial conflicts that arise from directly paying for review, we utilize censorship resistant blockchains to record all communication between the authors and the reviewers. Reviewers must stake their reputation on the review and must declare no financial conflicts in the review process other than the cryptocurrency incentivization for the review. Reviewers that simply rubber stamp questionable work to collect fees will earn a reputation for sloppy work and are unlikely to be hired again. Incentives can be weighted for initiation and completion of the review in a timely and accurate manner.

Manuscript for Review

This review will focus on the Dash Cryptocurrency funded Cannabis genome assembly project at Medicinal Genomics. Reviewers were recruited through Linked-In, Twitter and Facebook.

The incentive will be paid in Dash: $500 Initiation fee and a $500 completion fee.

A link to the reviewers CV or ORCHID ID will be placed on the review.

7 day review

Review scope

I. Genomics and Bioinformatics (1-2 reviewers to be selected)

Verify the Cannabis genome presented is the most complete Cannabis genome that exists as of its notarized publication time stamp on (August 17th, 2018). Various tools for verification may include BUSCO, Quast, FastQc, BLASR, SALSA, BLAST, Juicebox etc.

Genome sequence at Mega.nz

Assembly

• https://mega.nz/#!JMYlBapT!Ygq4bJruNAjB0GBUUvhVOdw8sT2ee2LgFQeJ9eDvVa0
• https://mega.nz/#!BZI2AQKB!l6wiPCYaagkLiGrnG4x87Vzl1cYi6shrJfXPXfrsRW8

Raw subread BAM files (no alignment)

• https://mega.nz/#!ZIISmCLb!6C-LXjxP3kQqkaaGmGnOSPXR-vRLGRJwo_VWSA0lRq0
• https://mega.nz/#!xF5ABabB!avBhqAL6eGm2yn63B1tFzHI5YVcpAKES2Lwj5tWc68Y
• https://mega.nz/#!xF5ABabB!avBhqAL6eGm2yn63B1tFzHI5YVcpAKES2Lwj5tWc68Y
• https://mega.nz/#!xQwUSKAC!fmiL9Ah7B8V7T07g9N0jlBwDe9iJb1Pja-GOJgxbHKI
• https://mega.nz/#!MM5CjQYK!50fQR5xI4uh_8yZ0Nz6qKt4LfxOFFdG1eHiyTjUjBwc
• https://mega.nz/#!hcxmHADB!PJMAOvzs2j7RU-L2iw4V1I4m_8uwxAQ0gFOsbX5FTjs
• https://mega.nz/#!dNp0TIJR!qVpO5PuxyUYipV3zgifXPJT9W1UBK4dd4G7HMvYaQ_A
• https://mega.nz/#!cNhSgYLT!9OcJDfaH-q0AktcuUBUuBkVjDvg3CQF4nRNDh7X37dE
• https://mega.nz/#!8AoSAYpL!4VSW-iHXmPiSgLrXwqtqZIf4P8u8n1hXdqacmnyVEjY
• https://mega.nz/#!1RhUHSiQ!Lmwk5usW_tAbCvZrVr33HAaE2uSdkJtONGDNhVY3e5I
• https://mega.nz/#!gdognIRb!78Nal8r3pkFWDVkgDrEhD5MmuVY2_3xOD3p0UDJenBw

October 18th, 2018 Version 6 BAM Files

• https://mega.nz/#!4RwDECxT!o01Qxzzzqx5OR4GBCbelu9Pk6oSwvGgCXfZQTG8u3dk
• https://mega.nz/#!9IRUDAhZ!lEdaRInGQ-YhoXCScoh0qkt0QA6CfQwIaVpteA4Dx_g
• https://mega.nz/#!AJRQiYKA!2MwnP8Lqm1hdJ8TEoqmspSYZEt88VKekaYOoS-Uwvzs

Phase Genomics HiC

• https://mega.nz/#!0QZCBIiQ!c1jPyCgprICAJh1mN0cFvODF0DQZuO9w0-J-xbsBleY
• https://mega.nz/#!gAgSlKDa!tzyn2cdokHU9GQlv_i_4DVpDRid8Zhq_niEFgNKzj18

Salsa output

• https://mega.nz/#!5dgTWSDT!1iAQK595oc-ZNsFbUWFqSPnIOeeyMkw3e_2Hlu_-4×0
• https://mega.nz/#!YR5ERI7I!0MNVhQc-mRjonjZiLI5P6hwVDL43VvPatUE9eBBGh8Q

Data Access and Notarization

• filename: jamaicanlion_falcon_unzip_arrow_haplotigs_160818.fasta.gz
• digest:db9216e4e1e1b72b1540ab7d9ae76462ebaaed5710e32e39363bfc9587bc73c0
• transaction id:73012ba6ef8b9af67a6b9e36974bd38c37c9c1d6e6ecab873e657b79f1da17fa
• filename: jamaicanlion_falcon_unzip_arrow_primary_160818.fasta.gz
• digest:21440180f4e06755c701fdc3f863d9d3edf5fdbea721ca122bce84ee672061dd
• transaction id:0653c54153493f2b8d6c1cee66c869454c3ff904aa18ed18f92f608ad7383a77

3.8Mb N50 Assemblies

• https://s3.amazonaws.com/C.Sativa/Jamaican_Lion_polished_alt_haplotigs_181018.fa.gz

SHA-256 Hash- e6eb30ee17a1d85a3bbba9c97b8f3e03bfa8f6228e97c9678ca20635851e9352  

• https://s3.amazonaws.com/C.Sativa/Jamaican_Lion_polished_primary_181018.fa.gz

SHA-256 Hash- 43d377e3521c584a24c000a8f13af89efdd25ed61a911f6d6c5dd73d4eb2ef28  

Proximo assembly (draft)

• https://s3.amazonaws.com/C.Sativa/jlion_newasm_filt.fasta.gz

NCBI

• https://submit.ncbi.nlm.nih.gov/api/2.0/files/g9c4akug/jamaican_lion_dash_arrow_primary.fsa/?format=attachment
• https://www.ncbi.nlm.nih.gov/bioproject/?term=Jamaican%20Lion

Table 2 supplement: Sequence of synthase genes

https://mega.nz/#!lUp1XaRC!U6Jz9pCM7oFSuuH6vxz6lkDX8i2_gg7CKzql4rZWW5k

II. Economics, Cryptocurrencies and Blockchain technologies (1 reviewer selected)

Review of Cryptocurrency introduction and methods. Familiarity with Trezor.io, shapeshifter and coinbase is helpful. Familiarity with Dash, Bitcoin and Bitcoin Cash history.

The Draft Manuscript is posted at the below OSF link.

https://osf.io/7d968/

DASH HASH of the document

1ef9f80da9375149ab266f289599ddbb097c3e4af66271fbceb5993031822904

The online lab notebook for this project can be found at:

Cryptocurrency Peer Reviewer: David Mondrus

DASH address: XvX1WqLbgwstpTQdWSzSVahGw3GsEC2Zk3

bio-bitcoin

david-mondrus-resume-ceo-3

Reviewer acknowledges that the only financial connection to the authors is the $1000 Peer Review incentive. No other financial conflicts exist.

Email communications to initiate review-

re_-crypto-peer-review_1

Dash POE

b445be1992065f1ac851c0d2fc55ec7b4c48fbe67f56edb647e4d7f60e60db33

re_-preprint-is-live

Dash POE

def2c9b00dd700c36c7e41a599a72ce579218cbb1fb986d0fd3d880c62aef5ef

Document with David Mondrus comments

cryptocurrencies-and-zero-mode-wave-guides_osf

Dash POE

2c1b22f424e4b55439c377558788afe265145d6b4aed73d1c016a90ec54ebfae

Bioinformatics Reviewer

Tim Fallon, PhD candidate

https://photocyte.github.io/about/

Email communication

DASH notarization

20181114_trf_dash_cannabis_review

Darren Abbey, PhD

https://orcid.org/0000-0003-4667-8004

Email Communication

Dash Notarization:

cryptocurrencies-and-zero-mode-wave-guides_osf.daa-01