Cannabis and Cancer – Journal Links Compiled by Dr. Robert Melamede

Cannabis and Cancer – Journal Links Compiled by Dr. Robert Melamede

  • 1. Hsu, E. S. A review of granisetron, 5-hydroxytryptamine3 receptor antagonists, and other antiemetics. Am J Ther 17, 476-486 (2010).
  • 2. Jordan, K. et al. Antiemetics in children receiving chemotherapy. MASCC/ESMO guideline update 2009. Support Care Cancer (2010).
  • 3. Liu, W. M., Fowler, D. W. & Dalgleish, A. G. Cannabis-Derived Substances in Cancer Therapy – an Emerging Anti-Inflammatory Role for the Cannabinoids. Curr Clin Pharmacol (2010).
  • 4. Larrinaga, G. et al. Cannabinoid CB1 Receptor Is Down-regulated in Clear Cell Renal Cell Carcinoma. J Histochem Cytochem (2010).
  • 5. Lam, P. M., Marczylo, T. H. & Konje, J. C. Simultaneous measurement of three N- acylethanolamides in human bio-matrices using ultra performance liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem (2010).
  • 6. Thapa, D. et al. Novel hexahydrocannabinol analogs as potential anti-cancer agents inhibit cell proliferation and tumor angiogenesis. Eur J Pharmacol (2010).
  • 7. Amoako, A. A. et al. Quantitative analysis of anandamide and related acylethanolamides in human seminal plasma by ultra performance liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2010).
  • 8. Peat, S. Using cannabinoids in pain and palliative care. Int J Palliat Nurs 16, 481- 485 (2010).
  • 9. Hu, G., Ren, G. & Shi, Y. The putative cannabinoid receptor GPR55 promotes cancer cell proliferation. Oncogene (2010).
  • 10. Karschner, E. L., Darwin, W. D., Goodwin, R. S., Wright, S. & Huestis, M. A. Plasma Cannabinoid Pharmacokinetics following Controlled Oral {Delta}9- Tetrahydrocannabinol and Oromucosal Cannabis Extract Administration. Clin Chem (2010).
  • 11. Duran, M. et al. Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting. Br J Clin Pharmacol 70, 656-663 (2010).
  • 12. Lee, T. Y., Lee, K. C. & Chang, H. H. Modulation of the cannabinoid receptors by andrographolide attenuates hepatic apoptosis following bile duct ligation in rats with fibrosis. Apoptosis (2010).
  • 13. Yang, Y. Y., Liu, H., Nam, S. W., Kunos, G. & Lee, S. S. Mechanisms of TNFalpha-induced cardiac dysfunction in cholestatic bile duct-ligated mice: Interaction between TNFalpha and endocannabinoids. J Hepatol (2010).
  • 14. Labar, G., Wouters, J. & Lambert, D. M. A Review on the Monoacylglycerol Lipase: At the Interface between Fat and Endocannabinoid Signalling. Curr Med Chem (2010).
  • 15. Frampton, G., Coufal, M., Li, H., Ramirez, J. & Demorrow, S. Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling. Exp Cell Res (2010).
  • 16. Xian, X. S. et al. Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells. J Cell Biochem (2010).
  • 17. Jesus, M. L. et al. Opposite changes in cannabinoid CB(1) and CB(2) receptor expression in human gliomas. Neurochem Int (2010).
  • 18. Laezza, C. et al. Inhibition of HMG-CoA reductase activity and of Ras farnesylation mediate antitumor effects of anandamide in human breast cancer cell. Endocr Relat Cancer (2010).
  • 19. Wu, W. J. et al. [Membrane cholesterol mediates the endocannabinoids-anandamide effection on HepG2 cells.]. Zhonghua Gan Zang Bing Za Zhi 18, 204-208 (2010).
  • 20. Fonseca, B. M. et al. N-Acylethanolamine Levels and Expression of Their Metabolizing Enzymes during Pregnancy. Endocrinology (2010).
  • 21. Fernandez-Solari, J., Prestifilippo, J. P., Ossola, C. A., Rettori, V. & Elverdin, J. C. Participation of the endocannabinoid system in lipopolysaccharide-induced inhibition of salivary secretion. Arch Oral Biol (2010).
  • 22. Whyte, D. A. et al. Cannabinoids Inhibit Cellular Respiration of Human Oral Cancer Cells. Pharmacology 85, 328-335 (2010).
  • 23. Soneji, N. D., Paule, C. C., Mlynarczyk, M. & Nagy, I. Effects of cannabinoids on capsaicin receptor activity following exposure of primary sensory neurons to inflammatory mediators. Life Sci (2010).
  • 24. Reiss, C. S. Cannabinoids and Viral Infections. Pharmaceuticals (Basel) 3, 1873- 1886 (2010).
  • 25. Santha, P., Jenes, A., Somogyi, C. & Nagy, I. The endogenous cannabinoid anandamide inhibits transient receptor potential vanilloid type 1 receptor-mediated currents in rat cultured primary sensory neurons. Acta Physiol Hung 97, 149-158 (2010).
  • 26. Ford, L. A. et al. A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells. Br J Pharmacol 160, 762-771 (2010).
  • 27. Brown, I. et al. Cannabinoid receptor dependent and independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor positive and negative prostate cancer cell lines. Carcinogenesis (2010).
  • 28. Caffarel, M. M. et al. Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition. Mol Cancer 9, 196 (2010).
  • 29. Park, J. Y. et al. Alcohol intake and risk of colorectal cancer: Results from the UK Dietary Cohort Consortium. Br J Cancer (2010).
  • 30. Linsalata, M. et al. Effects of anandamide on polyamine levels and cell growth in human colon cancer cells. Anticancer Res 30, 2583-2589 (2010).
  • 31. Marcu, J. P. et al. Cannabidiol Enhances the Inhibitory Effects of {Delta}9- Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival. Mol Cancer Ther (2010).
  • 32. Yang, Q., Liu, H. Y., Zhang, Y. W., Wu, W. J. & Tang, W. X. Anandamide induces cell death through lipid rafts in hepatic stellate cells. J Gastroenterol Hepatol (2010).
  • 33. Petrosino, S. & Di Marzo, V. FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels. Curr Opin Investig Drugs 11, 51-62 (2010).
  • 34. Patel, K. D., Davison, J. S., Pittman, Q. J. & Sharkey, K. A. Cannabinoid CB(2) Receptors in Health and Disease. Curr Med Chem (2010).
  • 35. Martini, L., Thompson, D., Kharazia, V. & Whistler, J. L. Differential Regulation of Behavioral Tolerance to WIN55,212-2 by GASP1. Neuropsychopharmacology (2010).
  • 36. Gao, M., Wang, M., Miller, K. D., Hutchins, G. D. & Zheng, Q. H. Synthesis and in vitro biological evaluation of carbon-11-labeled quinoline derivatives as new candidate PET radioligands for cannabinoid CB2 receptor imaging. Bioorg Med Chem (2010).
  • 37. Ward, H., Luben, R. N., Wareham, N. J. & Khaw, K. T. CHD risk in relation to alcohol intake from categorical and open-ended dietary instruments. Public Health Nutr 1-8 (2010).
  • 38. Yang, Y. Y., Liu, H., Nam, S. W., Kunos, G. & Lee, S. S. Mechanisms of TNFalpha-induced cardiac dysfunction in cholestatic bile duct-ligated mice: interaction between TNFalpha and endocannabinoids. J Hepatol 53, 298-306 (2010).
  • 39. Miranville, A., Herling, A. W., Biemer-Daub, G. & Voss, M. D. Reversal of Inflammation-Induced Impairment of Glucose Uptake in Adipocytes by Direct Effect of CB1 Antagonism on Adipose Tissue Macrophages. Obesity (Silver Spring) (2010).
  • 40. Kawamata, T., Niiyama, Y., Yamamoto, J. & Furuse, S. Reduction of bone cancer pain by CB1 activation and TRPV1 inhibition. J Anesth (2010).
  • 41. Fowler, C. J. et al. Targeting the Endocannabinoid System for the Treatment of Cancer – A Practical View. Curr Top Med Chem (2010).
  • 42. Taylor, A. H., Abbas, M. S., Habiba, M. A. & Konje, J. C. Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle. Histochem Cell Biol (2010).
  • 43. Gallotta, D. et al. Rimonabant-induced apoptosis in leukemia cell lines: activation of caspase-dependent and -independent pathways. Biochem Pharmacol (2010).
  • 44. Mukhopadhyay, B. et al. Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-{gamma}. J Biol Chem (2010).
  • 45. De Laurentiis, A., Fernandez Solari, J., Mohn, C., Zorrilla Zubilete, M. & Rettori, V. Endocannabinoid System Participates in Neuroendocrine Control of Homeostasis. Neuroimmunomodulation 17, 153-156 (2010).
  • 46. Thors, L. et al. Fatty Acid Amide Hydrolase in Prostate Cancer: Association with Disease Severity and Outcome, CB(1) Receptor Expression and Regulation by IL-4. PLoS One 5, (2010).
  • 47. Phillips, R. S. et al. Antiemetic medication for prevention and treatment of chemotherapy induced nausea and vomiting in childhood. Cochrane Database Syst Rev 9, CD007786 (2010).
  • 48. Olea-Herrero, N., Vara, D., Malagarie-Cazenave, S. & Diaz-Laviada, I. The cannabinoid R(+)methanandamide induces IL-6 secretion by prostate cancer PC3 cells. J Immunotoxicol (2009).
  • 49. Izzo, A. A., Borrelli, F., Capasso, R., Di Marzo, V. & Mechoulam, R. Non- psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci (2009).
  • 50. Wainwright, C. & McGrath, J. Editorial. Br J Pharmacol 158, 393-394 (2009). 51. Guindon, J. & Hohmann, A. G. The Endocannabinoid System and Pain. CNS
  • Neurol Disord Drug Targets (2009).
  • 52. Horn, C. C., Still, L., Fitzgerald, C. & Friedman, M. I. Food restriction, refeeding, and gastric fill fail to affect emesis in musk shrews. Am J Physiol Gastrointest Liver Physiol (2009).
  • 53. Freimuth, N., Ramer, R. & Hinz, B. Antitumorigenic effects of cannabinoids beyond apoptosis. J Pharmacol Exp Ther (2009).
  • 54. Tournier, N. et al. Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol 1-11 (2009).
  • 55. Johnson, J. R. et al. Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients With Intractable Cancer-Related Pain. J Pain Symptom Manage (2009).
  • 56. Qamri, Z. et al. Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer. Mol Cancer Ther (2009).
  • 57. Rask-Andersen, M., Olszewski, P. K., Levine, A. S. & Schioth, H. B. Molecular mechanisms underlying anorexia nervosa: Focus on human gene association studies and systems controlling food intake. Brain Res Rev (2009).
  • 58. De Filippis, D. et al. LEVELS OF ENDOCANNABINOIDs AND PALMITOYLETHANOLAMIDE AND THEIR PHARMACOLOGICAL MANIPULATION IN CHRONIC GRANULOMATOUS INFLAMMATION IN RATs. Pharmacol Res (2009).
  • 59. Leelawat, S., Leelawat, K., Narong, S. & Matangkasombut, O. The Dual Effects of Delta(9)-Tetrahydrocannabinol on Cholangiocarcinoma Cells: Anti-Invasion Activity at Low Concentration and Apoptosis Induction at High Concentration. Cancer Invest (2009).
  • 60. Ramer, R., Merkord, J., Rohde, H. & Hinz, B. Cannabidiol Inhibits Cancer Cell Invasion Via Upregulation Of Tissue Inhibitor Of Matrix Metalloproteinases-1. Biochem Pharmacol (2009).
  • 61. Brighton, P. J. et al. Characterization of anandamide-stimulated cannabinoid receptor signaling in human ULTR myometrial smooth muscle cells. Mol Endocrinol (2009).
  • 62. Kingsley, P. J. & Marnett, L. J. Analysis of endocannabinoids, their congeners and COX-2 metabolites. J Chromatogr B Analyt Technol Biomed Life Sci (2009).
  • 63. Takeda, S., Yamamoto, I. & Watanabe, K. Modulation of Delta(9)- tetrahydrocannabinol-induced MCF-7 breast cancer cell growth by cyclooxygenase and aromatase. Toxicology 259, 25-32 (2009).
  • 64. Cotter, J. Efficacy of Crude Marijuana and Synthetic Delta-9-Tetrahydrocannabinol as Treatment for Chemotherapy-Induced Nausea and Vomiting: A Systematic Literature Review. Oncol Nurs Forum 36, 345-352 (2009).
  • 65. Salazar, M. et al. Cannabinoid action induces autophagymediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest 119, 1359-1372 (2009).
  • 66. Wegener, N. & Koch, M. Neurobiology and Systems Physiology of the Endocannabinoid System. Pharmacopsychiatry 42, S79-S86 (2009).
  • 67. Brizzi, A. et al. New Resorcinol-Anandamide “Hybrids” as Potent Cannabinoid Receptor Ligands Endowed with Antinociceptive Activity in Vivo. J Med Chem (2009).
  • 68. Izzo, A. A. & Camilleri, M. Cannabinoids in intestinal inflammation and cancer. Pharmacol Res (2009).
  • 69. Yin, H. et al. Lipid G-protein-coupled Receptor Ligand Identification Using beta – arrestin Pathhunter Assay. J Biol Chem (2009).
  • 70. Villanueva, A. et al. Central Cannabinoid-1 Receptor Antagonist Administration Prevents Endotoxic Hypotension Affecting Norepinephrine Release in the Preoptic Anterior Hypothalamic Area. Shock (2009).
  • 71. Farquhar-Smith, W. P. Do cannabinoids have a role in cancer pain management? Curr Opin Support Palliat Care 3, 7-13 (2009).
  • 72. Navari, R. M. Antiemetic control: toward a new standard of care for emetogenic chemotherapy. Expert Opin Pharmacother 10, 629-644 (2009).
  • 73. Oesch, S. et al. Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma. Mol Cancer Ther (2009).
  • 74. Furuse, S. et al. Reduction of Bone Cancer Pain by Activation of Spinal Cannabinoid Receptor 1 and Its Expression in the Superficial Dorsal Horn of the Spinal Cord in a Murine Model of Bone Cancer Pain. Anesthesiology (2009).
  • 75. Schley, M. et al. Predominant CB2 receptor expression in endothelial cells of glioblastoma in humans. Brain Res Bull 79, 333-337 (2009).
  • 76. Udler, M. S. et al. Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer. Int J Cancer (2009).
  • 77. Luca, T. et al. The CB(1)/CB(2) receptor agonist WIN-55,212-2 reduces viability of human Kaposi’s sarcoma cells in vitro. Eur J Pharmacol (2009).
  • 78. Galal, A. M. et al. Naturally Occurring and Related Synthetic Cannabinoids and their Potential Therapeutic Applications. Recent Pat CNS Drug Discov 4, 112-136 (2009).
  • 79. Liang, C. et al. A Population-Based Case-Control Study of Marijuana Use and Head and Neck Squamous Cell Carcinoma. Cancer Prev Res (Phila Pa) (2009).
  • 80. Surtees, P. G., Wainwright, N. W., Luben, R. N., Khaw, K. T. & Bingham, S. A. No evidence that social stress is associated with breast cancer incidence. Breast Cancer Res Treat (2009).
  • 81. Biro, T., Toth, B. I., Hasko, G., Paus, R. & Pacher, P. The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. Trends Pharmacol Sci (2009).
  • 82. Han, K. H. et al. CB1 and CB2 Cannabinoid Receptors Differentially Regulate the Production of Reactive Oxygen Species by Macrophages. Cardiovasc Res (2009).
  • 83. Oesch, S. & Gertsch, J. Cannabinoid receptor ligands as potential anticancer agents – high hopes for new therapies? J Pharm Pharmacol 61, 839-853 (2009).
  • 84. Gustafsson, K., Sander, B., Bielawski, J., Hannun, Y. A. & Flygare, J. Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism. Mol Cancer Res 7, 1086-1098 (2009).
  • 85. Ramesh, Shukla, N. K. & Bhatnagar, S. Phantom breast syndrome. Indian J Palliat Care 15, 103-107 (2009).
  • 86. Surtees, P. G. et al. No association between APOE and major depressive disorder in a community sample of 17,507 adults. J Psychiatr Res (2009).
  • 87. Dunning, A. M. et al. Association of ESR1 gene tagging SNPs with breast cancer risk. Hum Mol Genet (2009).
  • 88. Van Dross, R. T. Metabolism of anandamide by COX-2 is necessary for endocannabinoid-induced cell death in tumorigenic keratinocytes. Mol Carcinog (2009).
  • 89. Lorente, M. et al. Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis. Glia (2009).
  • 90. Pisanti, S. et al. Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents. Best Pract Res Clin Endocrinol Metab 23, 117-131 (2009).
  • 91. Froger, N. et al. Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments. J Neurochem 111, 1383-1397 (2009).
  • 92. Madeddu, C. & Mantovani, G. An update on promising agents for the treatment of cancer cachexia. Curr Opin Support Palliat Care (2009).
  • 93. Mantovani, G. & Madeddu, C. Cancer cachexia: medical management. Support Care Cancer (2009).
  • 94. Olea-Herrero, N., Vara, D., Malagarie-Cazenave, S. & Diaz-Laviada, I. Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: Involvement of CB(2). Br J Cancer (2009).
  • 95. Zhao, P., Leonoudakis, D., Abood, M. E. & Beattie, E. Cannabinoid Receptor Activation Reduces TNFalpha-Induced Surface Localization of AMPAR-Type Glutamate Receptors and Excitotoxicity. Neuropharmacology (2009).
  • 96. Pisanti, S. & Bifulco, M. Endocannabinoid system modulation in cancer biology and therapy. Pharmacol Res 60, 107-116 (2009).
  • 97. Moayyeri, A. et al. Estimation of absolute fracture risk among middle-aged and older men and women: the EPIC-Norfolk population cohort study. Eur J Epidemiol (2009).
  • 98. Santoro, A. et al. Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon. Int J Cancer (2009).
  • 99. Wang, Q. et al. Pretreatment With Electroacupuncture Induces Rapid Tolerance to Focal Cerebral Ischemia Through Regulation of Endocannabinoid System. Stroke (2009).
  • 100. Gallant, M., Odei-Addo, F., Frost, C. L. & Levendal, R. A. Biological effects of THC and a lipophilic cannabis extract on normal and insulin resistant 3T3-L1 adipocytes. Phytomedicine (2009).
  • 101. Salazar, M. et al. Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest (2009).
  • 102. El-Talatini, M. R. et al. Localisation and function of the endocannabinoid system in the human ovary. PLoS ONE 4, e4579 (2009).
  • 103. Keeley, P. W. Nausea and vomiting in people with cancer and other chronic diseases. Clin Evid (Online) 2009, (2009).
  • 104. Alpini, G. & Demorrow, S. Chapter 18 Changes in the Endocannabinoid System May Give Insight into new and Effective Treatments for Cancer. Vitam Horm 81C, 469-485 (2009).
  • 105. Bifulco, M., Santoro, A., Laezza, C. & Malfitano, A. M. Chapter 7 Cannabinoid Receptor CB1 Antagonists State of the Art and Challenges. Vitam Horm 81, 159- 189 (2009).
  • 106. Wang, J. et al. Expression and secretion of N-acylethanolamine-hydrolyzing acid amidase in human prostate cancer cells. J Biochem (2008).
  • 107. Zuardi, A. W. Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action. Rev Bras Psiquiatr 30, 271-280 (2008).
  • 108. Khasabova, I. A. et al. A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer pain. J Neurosci 28, 11141-11152 (2008).
  • 109. Eichele, K., Ramer, R. & Hinz, B. R(+)-Methanandamide-Induced Apoptosis of Human Cervical Carcinoma Cells Involves A Cyclooxygenase-2-Dependent Pathway. Pharm Res (2008).
  • 110. Demorrow, S. et al. Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation. Am J Physiol Gastrointest Liver Physiol 294, G506-19 (2008).
  • 111. Van der Kooy, F., Pomahacova, B. & Verpoorte, R. Cannabis Smoke Condensate II: Influence of Tobacco on Tetrahydrocannabinol Levels. Inhal Toxicol 1 (2008).
  • 112. Burstein, S. & Salmonsen, R. Acylamido analogs of endocannabinoids selectively inhibit cancer cell proliferation. Bioorg Med Chem (2008).
  • 113. Czifra, G. et al. Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma. J Cancer Res Clin Oncol (2008).
  • 114. Lissoni, P. et al. The endocannabinoid anandamide neither impairs in vitro T-cell function nor induces regulatory T-cell generation. Anticancer Res 28, 3743-3748 (2008).
  • 115. Giuliano, M. et al. Apoptosis induced in HepG2 cells by the synthetic cannabinoid WIN: Involvement of the transcription factor PPARgamma. Biochimie (2008).
  • 116. Purohit, V., Gao, B. & Song, B. J. Molecular Mechanisms of Alcoholic Fatty Liver. Alcohol Clin Exp Res (2008).
  • 117. Caffarel, M. M. et al. JunD is involved in the antiproliferative effect of Delta(9)- tetrahydrocannabinol on human breast cancer cells. Oncogene (2008).
  • 118. Casida, J. E., Nomura, D. K., Vose, S. C. & Fujioka, K. Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids. Chem Biol Interact (2008).
  • 119. Buznikov, G. A. et al. Amyloid Precursor Protein 96-110 and Beta-amyloid 1-42 Elicit Developmental Anomalies in Sea Urchin Embryos and Larvae That Are Alleviated By Neurotransmitter Analogs for Acetylcholine, Serotonin and Cannabinoids. Neurotoxicol Teratol (2008).
  • 120. Zheng, D. et al. The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development. Cancer Res 68, 3992-3998 (2008).
  • 121. Deutsch, S. I. et al. Current Status of Cannabis Treatment of Multiple Sclerosis with an Illustrative Case Presentation of a Patient with MS, Complex Vocal Tics, Paroxysmal Dystonia, and Marijuana Dependence Treated with Dronabinol. CNS Spectr 13, 393-403 (2008).
  • 122. Surtees, P. G. et al. Psychological distress, major depressive disorder, and risk of stroke. Neurology 70, 788-794 (2008).
  • 123. De Petrocellis, L. et al. Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 (TRPA1) and melastatin type-8 (TRPM-8). J Pharmacol Exp Ther (2008).
  • 124. Blazquez, C. et al. Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res 68, 1945-1952 (2008).
  • 125. Endsley, M. P. et al. Expression and Function of Fatty Acid Amide Hydrolase in Prostate Cancer. Int J Cancer (2008).
  • 126. Iribarne, M. et al. Cannabinoid Receptors in Conjunctival Epithelium: Identification and Functional Properties. Invest Ophthalmol Vis Sci (2008).
  • 127. Gustafsson, K. et al. Expression of Cannabinoid Receptors Type 1 and Type 2 in Non-hodkin Lymphoma: Growth Inhibition By Receptor Activation. Int J Cancer (2008).
  • 128. Bifulco, M., Malfitano, A. M., Pisanti, S. & Laezza, C. Endocannabinoids in endocrine and related tumours. Endocr Relat Cancer 15, 391-408 (2008).
  • 129. Widmer, M., Hanemann, O. & Zajicek, J. High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. J Neurosci Res (2008).
  • 130. Habayeb, O. M., Taylor, A. H., Bell, S. C., Taylor, D. J. & Konje, J. C. Expression of the Endocannabinoid System in Human First Trimester Placenta and its Role in Trophoblast Proliferation. Endocrinology (2008).
  • 131. Machado Rocha, F. C., Stefano, S. C., DE Cassia Haiek, R., Rosa Oliveira, L. M. & DA Silveira, D. X. Therapeutic use of Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: systematic review and meta-analysis. Eur J Cancer Care (Engl) (2008).
  • 132. Rahn, E. J. et al. Selective Activation of Cannabinoid CB2 Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats. J Pharmacol Exp Ther (2008).
  • 133. van Diepen, H., Schlicker, E. & Michel, M. C. Prejunctional and peripheral effects of the cannabinoid CB(1) receptor inverse agonist rimonabant (SR 141716). Naunyn Schmiedebergs Arch Pharmacol (2008).
  • 134. Gustafsson, S. B., Lindgren, T., Jonsson, M. & Jacobsson, S. O. Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil. Cancer Chemother Pharmacol (2008).
  • 135. von Bueren, A. O., Schlumpf, M. & Lichtensteiger, W. Delta(9)- tetrahydrocannabinol inhibits 17beta-estradiol-induced proliferation and fails to activate androgen and estrogen receptors in MCF7 human breast cancer cells. Anticancer Res 28, 85-89 (2008).
  • 136. Ramer, R. & Hinz, B. Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1. J Natl Cancer Inst 100, 59-69 (2008).
  • 137. Sarfaraz, S., Adhami, V. M., Syed, D. N., Afaq, F. & Mukhtar, H. Cannabinoids for cancer treatment: progress and promise. Cancer Res 68, 339-342 (2008).
  • 138. Warr, D. G. Chemotherapy- and cancer-related nausea and vomiting. Curr Oncol 15, S4-9 (2008).
  • 139. Jones, J. D., Carney, S. T., Vrana, K. E., Norford, D. C. & Howlett, A. C. Cannabinoid receptor-mediated translocation of NO-sensitive guanylyl cyclase and production of cyclic GMP in neuronal cells. Neuropharmacology 54, 23-30 (2008).
  • 140. Bari, M. et al. Type-1 cannabinoid receptors colocalize with caveolin-1 in neuronal cells. Neuropharmacology 54, 45-50 (2008).
  • 141. Blazquez, C. et al. Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity? Neuropharmacology 54, 235-243 (2008).
  • 142. Notarnicola, M. et al. Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines. Scand J Gastroenterol 43, 66-72 (2008).
  • 143. Shi, Y. et al. Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma. Cancer Gene Ther 15, 101-107 (2008).
  • 144. Massi, P. et al. 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. J Neurochem 104, 1091-1100 (2008).
  • 145. Rudolph, M. I. et al. The Influence of Mast Cell Mediators on Migration of SW756 Cervical Carcinoma Cells. J Pharmacol Sci 106, 208-218 (2008).
  • 146. Ware1, M. A., Daeninck, P. & Maida, V. A review of nabilone in the treatment of chemotherapy-induced nausea and vomiting. Ther Clin Risk Manag 4, 99-107 (2008).
  • 147. Russo, E. B. Cannabinoids in the management of difficult to treat pain. Ther Clin Risk Manag 4, 245-259 (2008).
  • 148. Diaz, P. et al. 6-Methoxy-N-alkyl Isatin Acylhydrazone Derivatives as a Novel Series of Potent Selective Cannabinoid Receptor 2 Inverse Agonists: Design, Synthesis, and Binding Mode Prediction. J Med Chem (2008).
  • 149. Sugamura, K. et al. Activated Endocannabinoid System in Coronary Artery Disease and Antiinflammatory Effects of Cannabinoid 1 Receptor Blockade on Macrophages. Circulation (2008).
  • 150. Chung, S. C. et al. A high cannabinoid CB(1) receptor immunoreactivity is associated with disease severity and outcome in prostate cancer. Eur J Cancer (2008).
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